Comorbid Depression and Sleep Disorder Case Study

The Case: The woman who liked late-night TV The Question: What to do when comorbid depression and sleep disorders are resistant to treatment The Dilemma: Continuous positive airway pressure (CPAP) may not be a reasonable option for treating apnea; polypharmacy is needed but complicated by adverse effects. Review the patient intake documentation, psychiatric history, patient file, medication history, etc. As you progress through each section, formulate a list of questions that you might ask the patient if he or she were in your office. · Based on the patient’s case history, consider other people in his or her life that you would need to speak to or get feedback from (i.e., family members, teachers, nursing home aides, etc.). · Consider whether any additional physical exams or diagnostic testing may be necessary for the patient. · Develop a differential diagnoses for the patient. Refer to the DSM-5 in this week’s Learning Resources for guidance. · Review the patient’s past and current medications. Refer to Stahl’s Prescriber’s Guide and consider medications you might select for this patient. · Review the posttest for the case study. Learning Resources Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). New York, NY: Cambridge University Press. Stahl, S. M. (2014b). The prescriber’s guide (5th ed.). New York, NY: Cambridge University Press. Review the following medications: For insomnia · alprazolam · amitriptyline · amoxapine · clomipramine · clonazepam · desipramine · diazepam · doxepin · flunitrazepam · flurazepam · hydroxyzine · imipramine · lorazepam · nortriptyline · ramelteon · temazepam · trazodone · triazolam · trimipramine · zaleplon · zolpidem American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author. Davidson, J. (2016). Pharmacotherapy of post-traumatic stress disorder: Going beyond the guidelines. British Journal of Psychiatry, 2(6), e16-e18. doi:10.1192/bjpo.bp.116.003707. Retrieved from http://bjpo.rcpsych.org/content/2/6/e16 Differential diagnoses The case Study PATIENT FILE The Case: The woman who liked late-night TV The Question: What to do when comorbid depression and sleep disorders are resistant to treatment The Dilemma: Continuous positive airway pressure (CPAP) may not be a reasonable option for treating apnea; polypharmacy is needed but complicated by adverse effects Pretest self-assessment question (answer at the end of the case) Which of the following hypnotic agents is less likely to be addictive, impair psychomotor function, or cause respiratory suppression? A. Ramelteon (Rozerem) B. Zolpidem (Ambien) C. Doxepin (Silenor) D. Temazepam (Restoril) E. A and C F. B and D G. None of the above Patient evaluation on intake • 70-year-old female with a chief complaint of “being sad” • Feels she had been doing well until her hearing began to diminish in both ears – Candidate for cochlear implants in the future, but this is a long way off – Despite the promise of improved hearing, she often has crying spells for no clear reason Psychiatric history • The patient has been without psychiatric disorder throughout her life • Has felt increasingly sad over the last year and these feelings were not triggered by an acute stressor • Lives alone with the help of a home aide – Her spouse died many years ago due to CAD – Despite her aide and her son who visits often, she is having a harder time coping with both instrumental and basic activities of daily living • She admits to full MDD symptoms Differential diagnoses – She is sad, has lost interest in things she used to enjoy, and is fatigued with poor focus and concentration – Denies feelings of guilt, worthlessness, or any suicidal thoughts – Appears mildly psychomotor slowed – Additionally states that sleep is “awful” ◦ Does not fall asleep easily as her legs “ache and jump” ◦ Takes frequent naps during the day as a result ◦ She admits to snoring frequently • There is no evidence of cognitive decline or memory problems • She has a supportive son who accompanies her to all appointments and helps provide her care Social and personal history • Graduated high school, was married, and raised her children • Denied any academic issues, learning disability, or ADHD symptoms growing up • Having and maintaining friendships has been easy and successful over the years • At times, she is lonely at home • Her mobility has declined somewhat, which limits her going out • Participates in activities at a local elders’ center • No history of drug or alcohol problems Medical history • HTN • Hypothyroidism • CAD • Anemia • Environmental allergies • Obesity Family history • Reports AUD throughout her extended family • MDD reportedly suffered by her mother Medication history • Never taken psychotropic medications Psychotherapy history • Recently, has gone to a few sessions of outpatient supportive psychotherapy, but her hearing loss makes this modality almost impossible – Hearing aids have failed to help – May be a candidate for cochlear implants • She has a fax machine at home and states that she and her therapist often fax notes back and forth, which she finds helpful as receiving them brightens her mood – Perhaps this is “supportive facsimile therapy” Differential diagnoses